Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases.
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| Abstract |
We report on the first clinical study based on optical coherence tomography (OCT) in combination with multiphoton tomography (MPT) and dermoscopy. 47 patients with a variety of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and autoimmune bullous skin diseases have been investigated with (i) state-of-the-art OCT systems for dermatology including multibeam swept source OCT, (ii) the femtosecond laser multiphoton tomograph, and (iii) dermoscopes. Dermoscopy provides two-dimensional color images of the skin surface. OCT images reflect modifications of the intratissue refractive index whereas MPT is based on nonlinear excitation of endogenous fluorophores and second harmonic generation. A stack of cross-sectional OCT "wide field" images with a typical field of view of 5 x 2 mm(2) gave fast information on the depth and the volume of the lesion. Multiphoton tomography provided 0.36 x 0.36 mm(2) horizontal/diagonal optical sections within seconds of a particular region of interest with superior submicron resolution down to a tissue depth of 200 mum. The combination of OCT and MPT provides a unique powerful optical imaging modality for early detection of skin cancer and other skin diseases as well as for the evaluation of the efficiency of treatments.
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| Authors | Karsten König, Marco Speicher, Rainer Bückle, Julia Reckfort, Gordon McKenzie, Julia Welzel, Martin J Koehler, Peter Elsner, Martin Kaatz |
| Journal | Journal of biophotonics (J Biophotonics) Vol. 2 Issue 6-7 Pg. 389-97 (Jul 2009) ISSN: 1864-0648 [Electronic] Germany |
| PMID | 19598177 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't) |
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