The immunohistochemical expression of growth hormone-releasing hormone receptor splice variant 1 is a favorable prognostic marker in colorectal cancer.

Abstract	Hypothalamic growth hormone (GH)-releasing hormone (GHRH) regulates the release of GH from the pituitary gland. The receptors for GHRH (GHRH-R) are expressed predominantly in the pituitary. Recent evidence demonstrates that splice variants of the GHRH receptor are also expressed in several nonpituitary tissues, both normal and tumoral, as well as in cancer cell lines. The aim of this study was to investigate the expression of the splice variant 1 (SV-1) of GHRH-R in colorectal cancer (CRC). Seventy patients who underwent partial colectomy for CRC were enrolled in the study. Immunohistochemical expression of SV-1 was studied in paraffin-embedded sections of patient tumor tissue. A cytoplasmic supranuclear expression of SV-1 was observed in CRC as well as in the normal colon mucosa. Tumor grade and pathological stage were negatively correlated with expression of SV-1 (P = 0.012 and P = 0.013, respectively). CRCs metastatic to the liver showed a lower expression of SV-1 than did primary tumors, but this difference was not statistically significant. Kaplan-Meier and Cox univariate survival analyses indicated an improved survival time in patients with high SV-1 compared with those with low GHRH-R expression, but this difference was not statistically significant. The immunohistochemical expression of SV-1 seems to be a favorable prognostic factor in CRC.
Authors	Elena Theophanous, Constantina Petraki, Andreas Scorilas, Vassilios Komborozos, George Veloudis, Jozsef L Varga, Marta Zarandi, Andrew V Schally, Michael Koutsilieris
Journal	Molecular medicine (Cambridge, Mass.) (Mol Med) 2009 Jul-Aug Vol. 15 Issue 7-8 Pg. 242-7 ISSN: 1528-3658 [Electronic] England
PMID	19593408 (Publication Type: Journal Article)
Chemical References	AXIN2 protein, human Axin Protein Biomarkers, Tumor Cadherins Cytoskeletal Proteins Protein Isoforms Receptors, Neuropeptide Receptors, Pituitary Hormone-Regulating Hormone somatotropin releasing hormone receptor
Topics	Adult Aged Aged, 80 and over Axin Protein Biomarkers, Tumor (biosynthesis) Cadherins (metabolism) Cohort Studies Colorectal Neoplasms (diagnosis, metabolism, pathology) Cytoskeletal Proteins (metabolism) Female Humans Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Staging Prognosis Proportional Hazards Models Protein Isoforms Receptors, Neuropeptide (biosynthesis) Receptors, Pituitary Hormone-Regulating Hormone (biosynthesis) Statistics, Nonparametric

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