HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Systemic hypertension in two patients with ASL deficiency: a result of nitric oxide deficiency?

Abstract
Argininosuccinic aciduria (ASA) is an inborn error of ureagenesis which if untreated leads to hyperammonemia, accumulation of argininosuccinic acid and arginine depletion. The presence of high blood pressure in patients with ASA has been reported so far as transient in one newborn. We describe the first two patients, one child and one young adult, with ASA and persistent systemic hypertension. Extensive evaluation of both patients excluded secondary causes of systemic hypertension. The intriguing link between nitric oxide (NO) production and hypertension lead us to hypothesize that the deficiency of endogenously synthesized arginine caused by ASL deficiency is responsible for the increased blood pressure.
AuthorsNicola Brunetti-Pierri, Ayelet Erez, Oleg Shchelochkov, William Craigen, Brendan Lee
JournalMolecular genetics and metabolism (Mol Genet Metab) 2009 Sep-Oct Vol. 98 Issue 1-2 Pg. 195-7 ISSN: 1096-7206 [Electronic] United States
PMID19592285 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Nitric Oxide
Topics
  • Adult
  • Argininosuccinic Aciduria
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Hypertension (enzymology)
  • Infant, Newborn
  • Male
  • Nitric Oxide (deficiency)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: