Abstract | BACKGROUND: METHODS: RESULTS: The plasma HEL level was significantly increased in patients with MetS, whereas neither plasma and urine 8-OHdG levels nor plasma total antioxidant status level was different in patients with MetS. Furthermore, the plasma HEL level was significantly and positively correlated with fasting plasma glucose, serum insulin, and homeostasis model assessment- insulin resistance index in all subjects. CONCLUSIONS: The oxidative stress is strongly associated with the presence of MetS but not related to the presence or severity of OSAS. Furthermore, we demonstrated that the plasma concentration of HEL is a more sensitive biomarker of oxidative stress in patients with MetS than the plasma and urine levels of 8-OHdG.
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Authors | Fumie Tokuda, Yoshichika Sando, Hiroki Matsui, Tomoyuki Yokoyama |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 338
Issue 2
Pg. 127-33
(Aug 2009)
ISSN: 0002-9629 [Print] United States |
PMID | 19590428
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Biomarkers
- N(epsilon)-hexanoyllysine
- 8-Hydroxy-2'-Deoxyguanosine
- Deoxyguanosine
- Lysine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Adult
- Antioxidants
(metabolism)
- Biomarkers
- Deoxyguanosine
(analogs & derivatives, blood, urine)
- Humans
- Lysine
(blood)
- Male
- Metabolic Syndrome
(blood)
- Middle Aged
- Oxidative Stress
- Sleep Apnea, Obstructive
(blood)
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