The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease.

Abstract

The serotonin 6 receptor is attracting attention as an etiological contributor in cognition deficits in diseases such as Alzheimer's disease, anxiety/depression and schizophrenia. In this review, we discuss the role of this recently discovered G protein-coupled receptor in cognition and memory, particularly in Alzheimer's disease. A surge in publications that describe the development of ligands for this receptor have recently come to light, underscoring the emerging interest in this receptor as a drug target. We also explore the current status of structure-activity relationship studies that have focused on the design of novel antagonists for the serotonin 6 receptor.

• Authors: Werner J Geldenhuys, Cornelis J Van der Schyf
• Journal: Expert review of neurotherapeutics (Expert Rev Neurother) Vol. 9 Issue 7 Pg. 1073-85 (Jul 2009) ISSN: 1744-8360 [Electronic] England
• PMID: 19589055 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, Serotonin
• Serotonin Antagonists
• serotonin 6 receptor

Topics

• Alzheimer Disease (complications)
• Animals
• Cognition Disorders (drug therapy, etiology)
• Drug Design
• Humans
• Models, Biological
• Receptors, Serotonin (metabolism)
• Serotonin Antagonists (chemistry, therapeutic use)
• Structure-Activity Relationship