Abstract | BACKGROUND: OBJECTIVE: DESIGN: This study prospectively measured citrulline in 6 groups of HIV-1 patients (n = 115): 1) undetectable viral load without chronic diarrhea (a; n = 40) and with protease inhibitor-associated toxic chronic diarrhea (b; n = 26), 2) detectable viral load and CD4 > 200/mm(3) without (a; n = 6) and with (b; n = 11) chronic diarrhea, and 3) detectable viral load and CD4 <200/mm(3) without chronic diarrhea (a; n = 7) and with opportunistic intestinal infections or HIV enteropathy (b; n = 25). The influence of diarrhea on citrulline was assessed by comparing the a and b subgroups with healthy control subjects (n = 100). RESULTS: CONCLUSIONS:
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Authors | Pascal Crenn, Pierre De Truchis, Nathalie Neveux, Tatiana Galpérine, Luc Cynober, Jean Claude Melchior |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 90
Issue 3
Pg. 587-94
(Sep 2009)
ISSN: 1938-3207 [Electronic] United States |
PMID | 19587086
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Protease Inhibitors
- Serum Albumin
- Citrulline
- C-Reactive Protein
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Topics |
- AIDS-Related Opportunistic Infections
(blood, therapy, virology)
- Adult
- Biomarkers
(blood, metabolism)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Citrulline
(blood)
- Diarrhea
(blood, therapy, virology)
- Enterocytes
(metabolism, virology)
- HIV Infections
(blood, therapy, virology)
- HIV-1
- Humans
- Middle Aged
- Parenteral Nutrition
- Prospective Studies
- Protease Inhibitors
(adverse effects)
- Serum Albumin
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