Edaxadiene: a new bioactive diterpene from Mycobacterium tuberculosis.

Abstract

Mycobacterium tuberculosis remains a widespread and devastating human pathogen. Presented here is the characterization of an atypical class I diterpene cyclase from M. tuberculosis that catalyzes an unusual cyclization reaction in converting the known M. tuberculosis metabolite halimadienyl diphosphate to a further cyclized novel diterpene, which we have termed edaxadiene, as it directly inhibits maturation of the phagosomal compartment in which the bacterium is taken up during infection.

• Authors: Francis M Mann, Meimei Xu, Xiaoming Chen, D Bruce Fulton, David G Russell, Reuben J Peters
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 131 Issue 48 Pg. 17526-7 (Dec 09 2009) ISSN: 1520-5126 [Electronic] United States
• PMID: 19583202 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Diterpenes
• edaxadiene

Topics

• Cyclization
• Diterpenes (chemistry, pharmacology)
• Kinetics
• Mycobacterium tuberculosis (chemistry)
• Phagosomes (drug effects, metabolism)