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Lithium-induced membranous glomerulonephropathy in a pediatric patient.

Abstract
Lithium-induced glomerular toxicity is an infrequent occurrence in pediatric patients. We report a 13-year-old patient presenting with clinical and laboratory evidence of renal insufficiency after long-term lithium use. Biopsy revealed membranous glomerulonephropathy. Discontinuation of the lithium treatment resulted in resolution of the symptoms and laboratory abnormalities. Other alkali metals have been implicated as risk factors for membranous glomerulonephropathy. To the best of our knowledge, this is the first reported case of lithium-induced glomerulonephropathy in a pediatric patient.
AuthorsGunjeet K Kala, Muniza Mogri, Edit Weber-Shrikant, James E Springate
JournalPediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 24 Issue 11 Pg. 2267-9 (Nov 2009) ISSN: 1432-198X [Electronic] Germany
PMID19582480 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antihypertensive Agents
  • Serum Albumin
  • Enalapril
  • Lithium
  • Creatinine
Topics
  • Adolescent
  • Antihypertensive Agents (therapeutic use)
  • Biopsy
  • Creatinine (blood)
  • Enalapril (therapeutic use)
  • Follow-Up Studies
  • Glomerulonephritis, Membranous (chemically induced, pathology)
  • Humans
  • Kidney (surgery, ultrastructure)
  • Kidney Glomerulus (pathology)
  • Lithium (toxicity)
  • Male
  • Serum Albumin (analysis)
  • Time Factors
  • Treatment Outcome

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