Abstract | OBJECTIVES: METHOD AND MATERIALS: The design was a case-control study. The setting was the laboratory of postgraduate students in the College of Pharmacy, University of Mosul, Iraq. Clinical evaluation of the paste was conducted in the outpatient clinic of the Oral Medicine Department, College of Dentistry, University of Baghdad, Iraq. The novel paste (named dexamucobase) was prepared under aseptic conditions and evaluated for its therapeutic effect in 53 patients with recurrent aphthous stomatitis, in comparison with 37 patients treated with triamcinolone acetonide in Orabase. RESULTS: Healing of the ulcer was significantly faster (P < .001), and adverse effects were significantly reduced (P < .01) for the dexamucobase treatment compared to Kenalog in Orabase. There was no significant difference in the speed of pain reduction between the dexamucobase treatment compared to Kenalog in Orabase. CONCLUSIONS: The novel dexamucobase was found to be equally effective in treating oral aphthous ulceration, with some advantages, as the widely used preparation Kenalog in Orabase.
|
Authors | Zinah Midhafer Al-Na'mah, Roy Carson, Imad Abdul Jabbar Thanoon |
Journal | Quintessence international (Berlin, Germany : 1985)
(Quintessence Int)
Vol. 40
Issue 5
Pg. 399-404
(May 2009)
ISSN: 1936-7163 [Electronic] Germany |
PMID | 19582244
(Publication Type: Controlled Clinical Trial, Journal Article)
|
Chemical References |
- Anti-Inflammatory Agents
- Ointments
- Dexamethasone
- Orabase
- Triamcinolone Acetonide
- Carboxymethylcellulose Sodium
|
Topics |
- Adolescent
- Adult
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Carboxymethylcellulose Sodium
(analogs & derivatives)
- Dexamethasone
(administration & dosage, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Ointments
(chemical synthesis)
- Stomatitis, Aphthous
(drug therapy)
- Treatment Outcome
- Triamcinolone Acetonide
(administration & dosage, therapeutic use)
- Young Adult
|