[The changes of content of TNF-alpha, nitric oxide and FeS-NO in patients blood with traumatic shock under Plaferon LB influence].

Abstract

There were examined 40 patients with traumatic shock and 10 healthy blood-donor (1-st group). The patients were divided into two groups: patients with traumatic shock based on standard program of intensive therapy and patients with traumatic shock based on standard program of intensive therapy plus Plaferone LB. The blood test was made on 1st and 5th day of stationary treatment. TNF-alpha was examined in blood plasma by immunophermetic method and NO, FeS-NO by electro-paramagnetic resonance method. It was revealed, that Plapherone LB has no affect on TNF-alpha concentration, but it modulates NO concentration.

• Authors: I M Nakashidze
• Journal: Georgian medical news (Georgian Med News) Issue 171 Pg. 76-8 (Jun 2009) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 19578221 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Ferric Compounds
• Neuropeptides
• Tumor Necrosis Factor-alpha
• plaferon
• ferric oxide
• Nitric Oxide

Topics

• Antioxidants (therapeutic use)
• Ferric Compounds (blood)
• Humans
• Neuropeptides (therapeutic use)
• Nitric Oxide (blood)
• Shock, Traumatic (blood, drug therapy)
• Tumor Necrosis Factor-alpha (blood)