[A pilot study on hypoxia of squamous cell carcinoma in oral cavity].

Abstract

OBJECTIVE:

To examine the extent of hypoxia in oral squamous cell carcinoma and investigate the factors related to the hypoxia.

METHODS:

An animal model of oral squamous cell carcinoma was established and single photon emission computed tomography (SPECT) with 99mTc-HL91 used to detect the hypoxia extent of the oral squamous cell carcinoma. The expression of hypoxia inducible factor 1 alpha (HIF-1alpha) was examined by immunohistochemical staining in 42 cases of formalin-fixed paraffin-embed squamous cell carcinoma.

RESULTS:

The uptake of 99mTc-HL91 in the tumor tissue was higher than that in normal tissue and had linear relation with the tumor size (P < 0.05). There was no HIF-1alpha expression in the normal oral mucosa. The expression of HIF-1alpha was high in oral mucosa carcinoma and closely related to the differentiation degree of tumor and metastasis of lymph node (P < 0.05).

CONCLUSIONS:

Tumor tissue had broad hypoxic region. HIF-1alpha highly expressed in oral squamous cell carcinoma and may play an important role in carcinogenesis and aggression.

• Authors: Wen-Shu Liu, Jian-Wei Shang, Yan Gao, Chuan-Bin Guo
• Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology (Zhonghua Kou Qiang Yi Xue Za Zhi) Vol. 44 Issue 5 Pg. 282-5 (May 2009) ISSN: 1002-0098 [Print] China
• PMID: 19575985 (Publication Type: Journal Article)

Chemical References

• Hypoxia-Inducible Factor 1, alpha Subunit

Topics

• Adult
• Aged
• Aged, 80 and over
• Animals
• Carcinoma, Squamous Cell (diagnostic imaging, metabolism, pathology)
• Female
• Humans
• Hypoxia
• Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Middle Aged
• Mouth Neoplasms (diagnostic imaging, metabolism, pathology)
• Pilot Projects
• Tomography, Emission-Computed, Single-Photon
• Xenograft Model Antitumor Assays