Promising effect of aromatase inhibitors on recurrent granulosa cell tumors.

Abstract

Recurring adult-type granulosa cell tumors of the ovary are usually treated by surgical resection followed by chemotherapy or radiation. However, the results of such treatment are disappointing. We describe 4 patients in whom recurrent ovarian granulosa cell tumors were treated with an aromatase inhibitor, with promising results.

• Authors: Jacob Korach, Tamar Perri, Mario Beiner, Tima Davidzon, Eddie Fridman, Gilad Ben-Baruch
• Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (Int J Gynecol Cancer) Vol. 19 Issue 5 Pg. 830-3 (Jul 2009) ISSN: 1525-1438 [Electronic] England
• PMID: 19574768 (Publication Type: Case Reports, Journal Article)

Chemical References

• Aromatase Inhibitors
• Nitriles
• Triazoles
• Anastrozole
• Letrozole

Topics

• Adult
• Aged
• Anastrozole
• Aromatase Inhibitors (therapeutic use)
• Female
• Granulosa Cell Tumor (drug therapy, pathology, surgery)
• Humans
• Letrozole
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy, pathology, surgery)
• Nitriles (therapeutic use)
• Ovarian Neoplasms (drug therapy, pathology, surgery)
• Ovariectomy
• Prognosis
• Treatment Outcome
• Triazoles (therapeutic use)