Abstract | OBJECTIVE: MATERIALS AND METHODS: In this study, new gene ontology technology was used to predict changes in the molecular function and biologic processes caused by the interaction between IRF-1 and HPV E7. RESULTS: The molecular function and biologic processes of IRF-1 and the combined IRF-1 and HPV E7 (IRF-1-E7) were derived using the GoFigure server. The combined IRF-1-E7 demonstrated more functions and biologic processes compared with IRF-1 alone. CONCLUSION: IRF-1-E7 was shown to be responsible for the positive regulation of many interleukins and to be involved in the differentiation of T-helper cells.
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Authors | Viroj Wiwanitkit |
Journal | Taiwanese journal of obstetrics & gynecology
(Taiwan J Obstet Gynecol)
Vol. 48
Issue 2
Pg. 138-41
(Jun 2009)
ISSN: 1875-6263 [Electronic] China (Republic : 1949- ) |
PMID | 19574175
(Publication Type: Journal Article)
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Chemical References |
- DNA-Binding Proteins
- E7 protein, Human papillomavirus type 18
- IRF1 protein, human
- Interferon Regulatory Factor-1
- Oncogene Proteins, Viral
- Papillomavirus E7 Proteins
- oncogene protein E7, Human papillomavirus type 16
- Interferons
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Topics |
- Cell Differentiation
(immunology)
- Cell Line, Tumor
- Cell Nucleus
(metabolism)
- DNA-Binding Proteins
(genetics, metabolism)
- Databases, Genetic
- Female
- Humans
- Interferon Regulatory Factor-1
(genetics, immunology, metabolism)
- Interferons
(metabolism)
- Oncogene Proteins, Viral
(genetics, metabolism)
- Papillomavirus E7 Proteins
- T-Lymphocytes, Helper-Inducer
(cytology, immunology)
- Uterine Cervical Neoplasms
(immunology, virology)
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