Abstract |
Gold nanoparticles targeting epidermal growth factor receptor via antibody conjugation undergo molecular specific aggregation when they bind to receptors on cell surfaces, leading to a red shift in their plasmon resonance frequency. Capitalizing on this effect, we demonstrate the efficacy of the molecular specific photoacoustic imaging technique using subcutaneous tumor-mimicking gelatin implants in ex-vivo mouse tissue. The results of our study suggest that highly selective and sensitive detection of cancer cells is possible using multiwavelength photoacoustic imaging and molecular specific gold nanoparticles.
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Authors | Srivalleesha Mallidi, Timothy Larson, Justina Tam, Pratixa P Joshi, Andrei Karpiouk, Konstantin Sokolov, Stanislav Emelianov |
Journal | Nano letters
(Nano Lett)
Vol. 9
Issue 8
Pg. 2825-31
(Aug 2009)
ISSN: 1530-6992 [Electronic] United States |
PMID | 19572747
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antibodies, Monoclonal
- Gold
- ErbB Receptors
|
Topics |
- Animals
- Antibodies, Monoclonal
(chemistry)
- Biosensing Techniques
(methods)
- Cell Line, Tumor
- Diagnostic Imaging
(methods)
- ErbB Receptors
(chemistry)
- Gold
(chemistry)
- Humans
- Metal Nanoparticles
- Mice
- Neoplasms
(diagnosis)
- Surface Plasmon Resonance
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