[Relationship of adiponectin and visfatin with fetus intrauterine growth].

To explore the correlation between adipocyte factors (adiponectin and visfatin) and fetus intrauterine growth.
Enzyme immunoassay was used to measure the adiponectin and visfatin levels in maternal and umbilical serum from 14 women with fetal growth restriction (FGR group), 14 women with macrosomia (macrosomia group) and 14 normal pregnant women (control group). The correlations of cord serum adiponectin and visfatin with maternal serum adiponectin and visfatin were analyzed.
(1) Serum visfatin levels in FGR mothers [(41.4 +/- 5.5)] microg/L were significantly higher than that in control women [(34.7 +/- 4.9) microg/L] and macrosomia mothers [(37.3 +/- 4.4) microg/L; P < 0.01, P < 0.05]. Serum adiponectin levels in macrosomia mothers [(4.1 +/- 1.3) mg/L] were significantly lower than that in control women [(6.6 +/- 1.5) mg/L] and FGR mothers [(6.4 +/- 1.3) mg/L; P < 0.01]. (2) Serum visfatin levels in FGR babies [(58.1 +/- 7.6) microg/L] were significantly increased than that in control newborns [(42.6 +/- 7.8) microg/L] and macrosomia babies [(48.5 +/- 9.1) microg/L; P < 0.01, P < 0.05]. Serum adiponectin levels in macrosomia babies [(6.5 +/- 1.3) mg/L] were significantly decreased than that in control newborns [(7.7 +/- 1.5) mg/L] and FGR babies [(7.7 +/- 1.0) mg/L; P < 0.05, P < 0.05]. (3) Maternal serum visfatin levels were positively correlated with umbilical serum visfatin levels (r = 0.720, P < 0.01). Umbilical serum adiponectin levels were higher than that in maternal serum, but there were no relationship between them (r = 0.301, P > 0.05).
The changes of visfatin and adiponectin levels may be related to the occurrence of FGR and fetal macrosomia.
AuthorsLi-xin Shang, Qing-ling Tang, Jing Wang, Fang Zhang, Nan Wu, Shu-he Wang, Ping Li
JournalZhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 44 Issue 4 Pg. 246-8 (Apr 2009) ISSN: 0529-567X [Print] China
PMID19570458 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adiponectin
  • Biomarkers
  • Nicotinamide Phosphoribosyltransferase
  • Adiponectin (blood)
  • Adult
  • Biomarkers (blood)
  • Birth Weight
  • Body Mass Index
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fetal Blood (chemistry)
  • Fetal Development
  • Fetal Growth Retardation (blood, physiopathology)
  • Fetal Macrosomia (blood, physiopathology)
  • Humans
  • Infant, Newborn
  • Nicotinamide Phosphoribosyltransferase (blood)
  • Pregnancy
  • Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: