Abstract | BACKGROUND: OBJECTIVES: METHODS: A literature review was performed, searching Medline and the clinicaltrials.gov database for all articles with the keywords ABT-874, IL-12/IL-23 and psoriasis. CONCLUSIONS: Although limited by small sample sizes, length of follow-up, and a lack of direct comparisons with other psoriasis treatments, initial data regarding the safety and efficacy of briakinumab for the treatment of psoriasis is promising. Ongoing Phase III trials may provide additional information regarding the relative efficacy and safety of briakinumab.
|
Authors | Xinaida Taligare Lima, Katrina Abuabara, Alexandra Boer Kimball, Hermenio Cavalcante Lima |
Journal | Expert opinion on biological therapy
(Expert Opin Biol Ther)
Vol. 9
Issue 8
Pg. 1107-13
(Aug 2009)
ISSN: 1744-7682 [Electronic] England |
PMID | 19569977
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Immunologic Factors
- Interleukin-23
- Interleukin-12
- briakinumab
|
Topics |
- Animals
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
- Biological Therapy
(methods)
- Clinical Trials as Topic
- Humans
- Immunologic Factors
(therapeutic use)
- Inflammation
- Interleukin-12
(metabolism)
- Interleukin-23
(metabolism)
- Models, Biological
- Psoriasis
(drug therapy)
- Treatment Outcome
|