Abstract | OBJECTIVE: METHODS: Twelve participants (age: 10 +/- 1 years; BMI: 35 +/- 14 kg/m(2)), with obstructive apnea-hypopnea syndrome ranging from mild to severe (2-36 events per hour) were administered 20 L/min of air through a nasal cannula. Standard sleep architecture, sleep-disordered breathing, and arousal indexes were assessed at baseline, on TNI, and on CPAP. Additional measures of the percentage of time with inspiratory flow limitation, respiratory rate, and inspiratory duty cycle were assessed at baseline and on TNI. RESULTS: TNI reduced the amount of inspiratory flow limitation, which led to a decrease in respiratory rate and inspiratory duty cycle. TNI improved oxygen stores and decreased arousals, which decreased the occurrence of obstructive apnea from 11 +/- 3 to 5 +/- 2 events per hour (P < .01). In the majority of children, the reduction in the apnea-hypopnea index on TNI was comparable to that on CPAP. CONCLUSIONS: TNI offers an alternative to therapy to CPAP in children with mild-to-severe sleep apnea. Additional studies will be needed to determine the efficacy of this novel form of therapy.
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Authors | Brian McGinley, Ann Halbower, Alan R Schwartz, Philip L Smith, Susheel P Patil, Hartmut Schneider |
Journal | Pediatrics
(Pediatrics)
Vol. 124
Issue 1
Pg. 179-88
(Jul 2009)
ISSN: 1098-4275 [Electronic] United States |
PMID | 19564298
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Catheterization
- Child
- Child, Preschool
- Continuous Positive Airway Pressure
- Equipment Design
- Female
- Humans
- Insufflation
(instrumentation, methods)
- Male
- Nasal Cavity
- Polysomnography
- Respiratory Therapy
(methods)
- Sleep Apnea, Obstructive
(therapy)
- Treatment Outcome
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