Abstract | BACKGROUND: METHODS: RESULTS:
Brain death induced a decrease in Pao(2)/Fio2 (p < 0.001) and increased the wet/dry weight of both apical (p = 0.01) and basal lobes (p = 0.03). NPY and CGRP concentrations were higher in the BAL fluid of brain-dead animals compared with controls (p = 0.02 and p = 0.02) and were positively correlated with the wet/dry weight ratio. NPY content in lung tissue was lower in brain-dead animals compared with controls (p = 0.04) and was negatively correlated with the wet/dry weight ratio. There were no differences in substance P concentrations between the groups. CONCLUSION: NPY was released from the lung tissue of brain-dead pigs, and its concentration was related to the extent of pulmonary edema. NPY may be one of several crucial mediators of neurogenic pulmonary edema, raising the possibility of treatment with NPY-antagonists to increase the number of available lung donors.
|
Authors | Anne Barklin, Elvar Theodorsson, Stig S Tyvold, Anders Larsson, Asger Granfeldt, Erik Sloth, Else Tonnesen |
Journal | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
(J Heart Lung Transplant)
Vol. 28
Issue 7
Pg. 725-32
(Jul 2009)
ISSN: 1557-3117 [Electronic] United States |
PMID | 19560702
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Biomarkers
- Neuropeptide Y
- Neuropeptides
- Substance P
- Calcitonin Gene-Related Peptide
|
Topics |
- Animals
- Biomarkers
(metabolism)
- Brain Death
(diagnosis, metabolism)
- Bronchoalveolar Lavage Fluid
- Calcitonin Gene-Related Peptide
(metabolism)
- Disease Models, Animal
- Female
- Lung
(metabolism)
- Neurogenic Inflammation
(metabolism)
- Neuropeptide Y
(metabolism)
- Neuropeptides
(metabolism)
- Predictive Value of Tests
- Pulmonary Edema
(diagnosis, etiology, metabolism)
- Substance P
(metabolism)
- Swine
- Vasoconstriction
(physiology)
- Vasodilation
(physiology)
|