Abstract |
A new cytotoxic casbane diterpene, named pekinenal, was isolated from the roots of Euphorbia pekinensis. Its structure was elucidated as 5alpha-hydroxy-1betaH,2alphaH-casba-3Z,7E,11E-triene-18-al by a combination of 1D- and 2D-NMR techniques and confirmed by X-ray crystallography. Pekinenal showed cytotoxic activity against all four human cancer cell lines tested.
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Authors | Qiao-Li Liang, Chuan-Chao Dai, Ji-Hong Jiang, Yu-Ping Tang, Jin-Ao Duan |
Journal | Fitoterapia
(Fitoterapia)
Vol. 80
Issue 8
Pg. 514-6
(Dec 2009)
ISSN: 1873-6971 [Electronic] Netherlands |
PMID | 19560525
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Diterpenes
- Plant Extracts
- pekinenal
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Topics |
- Antineoplastic Agents, Phytogenic
(isolation & purification, pharmacology, therapeutic use)
- Cell Line, Tumor
- Diterpenes
(isolation & purification, pharmacology, therapeutic use)
- Euphorbia
(chemistry)
- Humans
- Molecular Structure
- Neoplasms
(drug therapy)
- Phytotherapy
- Plant Extracts
(chemistry, pharmacology, therapeutic use)
- Plant Roots
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