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A new cytotoxic casbane diterpene from Euphorbia pekinensis.

Abstract
A new cytotoxic casbane diterpene, named pekinenal, was isolated from the roots of Euphorbia pekinensis. Its structure was elucidated as 5alpha-hydroxy-1betaH,2alphaH-casba-3Z,7E,11E-triene-18-al by a combination of 1D- and 2D-NMR techniques and confirmed by X-ray crystallography. Pekinenal showed cytotoxic activity against all four human cancer cell lines tested.
AuthorsQiao-Li Liang, Chuan-Chao Dai, Ji-Hong Jiang, Yu-Ping Tang, Jin-Ao Duan
JournalFitoterapia (Fitoterapia) Vol. 80 Issue 8 Pg. 514-6 (Dec 2009) ISSN: 1873-6971 [Electronic] Netherlands
PMID19560525 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Plant Extracts
  • pekinenal
Topics
  • Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology, therapeutic use)
  • Cell Line, Tumor
  • Diterpenes (isolation & purification, pharmacology, therapeutic use)
  • Euphorbia (chemistry)
  • Humans
  • Molecular Structure
  • Neoplasms (drug therapy)
  • Phytotherapy
  • Plant Extracts (chemistry, pharmacology, therapeutic use)
  • Plant Roots

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