Grade II atypical choroid plexus papilloma with normal karyotype.

Abstract

PURPOSE:

Cytogenetic studies of atypical choroid plexus papillomas (CPP) have been poorly described. In the present report, the cytogenetic investigation of an atypical CPP occurring in an infant is detailed.

METHODS:

CPP chromosome preparations were analyzed by giemsa-trypsin-banding (GTG-banding) and comparative genome hybridization (CGH).

RESULTS:

Conventional karyotype analysis of tumor culture showed a normal chromosome complement. The results were confirmed by CGH, showing normal hybridization patterns for the sample.

CONCLUSIONS:

To date, the few atypical CPPs described in the literature have shown disparate cytogenetic information. This is the first report of a normal chromosome complement in atypical CPP. The heterogenic genetic features observed in these small series may reflect the diverse genetic background of choroid plexus tumors in children.

• Authors: María Sol Brassesco, Elvis Terci Valera, Aline Paixão Becker, Ricardo Santos Oliveira, Carlos Alberto Scrideli, Hélio Rubens Machado, Luiz Gonzaga Tone
• Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 25 Issue 12 Pg. 1623-6 (Dec 2009) ISSN: 1433-0350 [Electronic] Germany
• PMID: 19554332 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Choroid Plexus (surgery)
• Choroid Plexus Neoplasms (genetics, surgery)
• Cytogenetics
• Humans
• Infant
• Karyotyping
• Male
• Papilloma, Choroid Plexus (genetics, surgery)
• Treatment Outcome