HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease.

Abstract
Two techniques employed for the early diagnosis of dementia are the imaging of amyloid-beta protein using positron emission tomography (PET) and voxel-based morphometry analysis of MRI (VBM-MRI). The purpose of this study was to evaluate the clinical utility of amyloid PET and VBM-MRI for the early diagnosis and tracking of the severity of Alzheimer's disease (AD). The neuritic plaque burden and gray matter losses were evaluated using [11C]BF-227-PET and VBM-MRI in 12 healthy controls, 13 subjects with mild cognitive impairment (MCI), including 6 who converted to AD and 7 who did not convert, and 15 AD patients. The AD patients and the MCI converters exhibited a neocortical retention of BF-227 and parahippocampal gray matter loss shown by VBM-MRI. The MCI converters were more clearly distinguished from the MCI non-converters in BF-227-PET than VBM-MRI. The combined sample of the MCI converters and AD patients showed a significant correlation of MMSE scores with the global gray matter loss, but not with the BF-227 retention. These findings suggest that amyloid PET using [11C]BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia.
AuthorsMasaaki Waragai, Nobuyuki Okamura, Katsutoshi Furukawa, Manabu Tashiro, Shozo Furumoto, Yoshihito Funaki, Motohisa Kato, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 285 Issue 1-2 Pg. 100-8 (Oct 15 2009) ISSN: 1878-5883 [Electronic] Netherlands
PMID19552926 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 2-(2-(2-dimethylaminothiazol-5-yl)ethenyl)-6-(2-(fluoro)ethoxy)benzoxazole
  • Benzoxazoles
  • Carbon Radioisotopes
  • Thiazoles
Topics
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease (diagnosis, diagnostic imaging, pathology)
  • Benzoxazoles
  • Brain (diagnostic imaging, pathology)
  • Carbon Radioisotopes
  • Cognition Disorders (diagnosis, diagnostic imaging, pathology)
  • Early Diagnosis
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Male
  • Neocortex (diagnostic imaging, pathology)
  • Nerve Fibers, Unmyelinated (pathology)
  • Neuropsychological Tests
  • Parahippocampal Gyrus (diagnostic imaging, pathology)
  • Plaque, Amyloid (pathology)
  • Positron-Emission Tomography (methods)
  • Severity of Illness Index
  • Signal Processing, Computer-Assisted
  • Thiazoles

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: