Abstract |
Two techniques employed for the early diagnosis of dementia are the imaging of amyloid-beta protein using positron emission tomography (PET) and voxel-based morphometry analysis of MRI (VBM-MRI). The purpose of this study was to evaluate the clinical utility of amyloid PET and VBM-MRI for the early diagnosis and tracking of the severity of Alzheimer's disease (AD). The neuritic plaque burden and gray matter losses were evaluated using [11C] BF-227-PET and VBM-MRI in 12 healthy controls, 13 subjects with mild cognitive impairment (MCI), including 6 who converted to AD and 7 who did not convert, and 15 AD patients. The AD patients and the MCI converters exhibited a neocortical retention of BF-227 and parahippocampal gray matter loss shown by VBM-MRI. The MCI converters were more clearly distinguished from the MCI non-converters in BF-227-PET than VBM-MRI. The combined sample of the MCI converters and AD patients showed a significant correlation of MMSE scores with the global gray matter loss, but not with the BF-227 retention. These findings suggest that amyloid PET using [11C] BF-227 is better suited for the prediction of conversion from MCI to AD, while VBM-MRI appears to be better suited for tracking the severity of dementia.
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Authors | Masaaki Waragai, Nobuyuki Okamura, Katsutoshi Furukawa, Manabu Tashiro, Shozo Furumoto, Yoshihito Funaki, Motohisa Kato, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 285
Issue 1-2
Pg. 100-8
(Oct 15 2009)
ISSN: 1878-5883 [Electronic] Netherlands |
PMID | 19552926
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-(2-(2-dimethylaminothiazol-5-yl)ethenyl)-6-(2-(fluoro)ethoxy)benzoxazole
- Benzoxazoles
- Carbon Radioisotopes
- Thiazoles
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(diagnosis, diagnostic imaging, pathology)
- Benzoxazoles
- Brain
(diagnostic imaging, pathology)
- Carbon Radioisotopes
- Cognition Disorders
(diagnosis, diagnostic imaging, pathology)
- Early Diagnosis
- Female
- Follow-Up Studies
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Neocortex
(diagnostic imaging, pathology)
- Nerve Fibers, Unmyelinated
(pathology)
- Neuropsychological Tests
- Parahippocampal Gyrus
(diagnostic imaging, pathology)
- Plaque, Amyloid
(pathology)
- Positron-Emission Tomography
(methods)
- Severity of Illness Index
- Signal Processing, Computer-Assisted
- Thiazoles
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