Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.

Abstract

The present study shows that JNJ 16259685-a selective antagonist of glutamate metabotropic receptor subtype 1 (mGluR1) injected in doses of 0.16 and 0.32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7.5 mg/kg ip) in rats. JNJ 16259685 inhibited locomotor and exploratory activity per se. These results may suggest an inhibitory influence of mGluR1 on the harmaline-induced motor disturbances.

• Authors: Wacław Kolasiewicz, Katarzyna Kuter, Jadwiga Wardas, Krystyna Ossowska
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 116 Issue 9 Pg. 1059-63 (Sep 2009) ISSN: 1435-1463 [Electronic] Austria
• PMID: 19551466 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• (3,4-dihydro-2H-pyrano(2,3)b-quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone
• Quinolines
• Receptors, Metabotropic Glutamate
• metabotropic glutamate receptor type 1
• Harmaline

Topics

• Animals
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drug Interactions
• Exploratory Behavior (drug effects)
• Harmaline
• Locomotion (drug effects)
• Male
• Quinolines (pharmacology)
• Rats
• Rats, Wistar
• Receptors, Metabotropic Glutamate (antagonists & inhibitors, metabolism)
• Time Factors
• Tremor (chemically induced, metabolism, physiopathology)