Severe monochlorobenzene-induced liver cell necrosis.

Abstract

Benzene derivatives can induce severe liver cell necrosis in animals. A case of a 40-year-old man whose daily consumption of alcohol was 200 g and who had a severe monochlorobenzene-induced liver necrosis is described. Liver biopsy specimen showed centrilobular and mediolobular necrosis, similar to that in mice after experimental bromobenzene administration. Monochlorobenzene serum concentration, assayed from day 3 to day 15 after poisoning, decreased monoexponentially with a half-life of 40.3 hours. Prostaglandin E1 was administered from day 3 to day 8. The patient ultimately recovered. The mechanism of monochlorobenzene-induced liver injury and the possible aggravating role of chronic alcohol consumption are discussed.

• Authors: G Babany, J Bernuau, A Cailleux, J F Cadranel, C Degott, S Erlinger, J P Benhamou
• Journal: Gastroenterology (Gastroenterology) Vol. 101 Issue 6 Pg. 1734-6 (Dec 1991) ISSN: 0016-5085 [Print] United States
• PMID: 1955139 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chlorobenzenes
• chlorobenzene

Topics

• Adult
• Alcoholism (metabolism)
• Chemical and Drug Induced Liver Injury
• Chlorobenzenes (blood, metabolism, poisoning)
• Humans
• Liver (pathology)
• Liver Diseases (blood, pathology)
• Male
• Necrosis