Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers.

Abstract

Chemoprevention of lung carcinogenesis is one approach to controlling the epidemic of lung cancer caused by cigarette smoking. The target for chemoprevention should be the activities of the multiple carcinogens, toxicants, co-carcinogens, tumour promoters and inflammatory compounds in cigarette smoke. At present there are many agents, both synthetic and naturally occurring, that prevent lung tumour development in well-established animal models. It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis.

• Authors: Stephen S Hecht, Fekadu Kassie, Dorothy K Hatsukami
• Journal: Nature reviews. Cancer (Nat Rev Cancer) Vol. 9 Issue 7 Pg. 476-88 (Jul 2009) ISSN: 1474-1768 [Electronic] England
• PMID: 19550424 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anticarcinogenic Agents
• N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine
• Thiocarbamates
• Inositol
• Budesonide
• Cysteine

Topics

• Animals
• Anticarcinogenic Agents (therapeutic use)
• Budesonide (therapeutic use)
• Clinical Trials as Topic
• Cysteine (analogs & derivatives, therapeutic use)
• Humans
• Inositol (therapeutic use)
• Lung Neoplasms (etiology, prevention & control)
• Smoking (adverse effects)
• Thiocarbamates (therapeutic use)