Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: The mechanism of action of PDT has been further elucidated. PDT induces an apoptotic, antiangiogenic as well as an immunomodulatory response. Interleukin-6, a bile duct epithelium growth factor correlating with tumor burden, decreases after PDT. The efficacy of PDT was confirmed in a comparative study in the United States. Patients with no visible mass on imaging studies, high serum albumin levels and treatment immediately after diagnosis seem to benefit most from PDT. Although it is recommended to perform PDT in bile ducts without stents in place, illumination through metal stents is possible if the light dose is adjusted. Meso-tetrahydroxyphenyl chlorine is a new potent photosensitizer for PDT of cholangiocarcinoma. SUMMARY: In advanced nonresectable cholangiocarcinoma, PDT is the only evidence-based treatment that improves survival when compared with stenting. Therefore, PDT should be offered to those who are unsuitable for surgery.
|
Authors | Maria-Anna Ortner |
Journal | Current opinion in gastroenterology
(Curr Opin Gastroenterol)
Vol. 25
Issue 5
Pg. 472-6
(Sep 2009)
ISSN: 1531-7056 [Electronic] United States |
PMID | 19550314
(Publication Type: Journal Article, Review)
|
Chemical References |
- Hematoporphyrins
- Interleukin-6
- Mesoporphyrins
- Photosensitizing Agents
- temoporfin
|
Topics |
- Apoptosis
- Bile Duct Neoplasms
(drug therapy)
- Bile Ducts, Intrahepatic
- Cholangiocarcinoma
(drug therapy)
- Hematoporphyrins
(therapeutic use)
- Humans
- Interleukin-6
(metabolism)
- Mesoporphyrins
(therapeutic use)
- Neovascularization, Pathologic
(drug therapy)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(therapeutic use)
- Stents
|