Can we improve fixation and outcomes? Use of bone substitutes.

Abstract

Hip fractures secondary to osteoporosis are common in the elderly. Stabilizing these fractures until union is achieved is a challenge due to poor bone stock and insufficient purchase of the implant to the bone. The reported high rate of complications has prompted extensive research in the development of fixation techniques. Furthermore, manipulation of both the local fracture environment in terms of application of growth factors, scaffolds, and mesenchymal cells and the systemic administration of agents promoting bone formation and bone strength has been considered as a treatment option with promising results. There are only a few evidence-based studies reporting on fixation augmentation techniques. This article reports on the efficacy of bone graft substitutes for the fixation of hip fractures, in particular calcium phosphates, which have been used as granules, cements, and implant coatings.

• Authors: Antonio Moroni, Sune Larsson, Amy Hoang Kim, Letizia Gelsomini, Peter V Giannoudis
• Journal: Journal of orthopaedic trauma (J Orthop Trauma) Vol. 23 Issue 6 Pg. 422-5 (Jul 2009) ISSN: 1531-2291 [Electronic] United States
• PMID: 19550228 (Publication Type: Journal Article, Review)

Chemical References

• Bone Substitutes

Topics

• Bone Substitutes (therapeutic use)
• Combined Modality Therapy
• Evidence-Based Medicine
• Femoral Neck Fractures (diagnosis, therapy)
• Fracture Fixation, Internal (methods, trends)
• Humans