Abstract | BACKGROUND: METHODS: Using mice expressing a previously characterized Ets dominant repressor transgene in the intestinal epithelium ( Villin-En/Erm), we examined the consequences of blocking endogenous Ets-mediated transcriptional activation on tumorigenesis in the ApcMin model of intestinal carcinoma. RESULTS: En/Erm expression in the intestine, at levels not associated with overt crypt-villus dysmorphogenesis, results in a marked increase in tumor number in ApcMin animals. Moreover, when examined histologically, tumors from En/Erm-expressing animals show a trend toward greater stromal invasiveness. Detailed analysis of crypt-villus homeostasis in these En/Erm transgenic animals suggests increased epithelial turnover as one possible mechanism for the enhanced tumorigenesis. CONCLUSION: Our findings provide in vivo evidence for a tumor-restricting function of endogenous Ets factors in the intestinal epithelium.
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Authors | Paul Jedlicka, Xiaomei Sui, Arthur Gutierrez-Hartmann |
Journal | BMC cancer
(BMC Cancer)
Vol. 9
Pg. 197
(Jun 22 2009)
ISSN: 1471-2407 [Electronic] England |
PMID | 19545444
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA-Binding Proteins
- Etv5 protein, mouse
- Proto-Oncogene Proteins c-ets
- Transcription Factors
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Topics |
- Animals
- Carcinoma
(genetics)
- DNA-Binding Proteins
(genetics, physiology)
- Gene Expression Regulation, Neoplastic
- Genes, Dominant
- Immunohistochemistry
- Intestinal Neoplasms
(genetics)
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Models, Biological
- Models, Genetic
- Neoplasm Invasiveness
- Proto-Oncogene Proteins c-ets
(genetics, physiology)
- Transcription Factors
(genetics, physiology)
- Transgenes
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