[A case of advanced ampullary carcinoma successfully resected after primary chemotherapy with s-1 and gemcitabine].

Abstract

The patient was a 53-year-old male who was admitted on an emergency basis with obstructive jaundice. He was diagnosed as having advanced ampullary carcinoma(T4 N0 H1, Stage IV b). To reduce the degree of obstructive jaundice, a self-expandable metallic stent was placed in the area of the biliary obstruction. Immediately after relief from obstructive jaundice, combination chemotherapy of S-1 and gemcitabine was given. Subsequently, CA19-9, the tumormarker level was reduced, the metastatic liver tumor disappeared, and the size of the primary lesion was remarkably reduced. Therefore, a curative surgical resection was done. This is a very instructive case for developing effective chemotherapy options to treat biliary tract cancers involving ampullary carcinoma.

• Authors: Tomoyoshi Ohno, Hiroki Koguchi, Aki Miura, Yoshito Tanaka, Masayuki Endo, Seijiro Matsunaga, Izumi Hasegawa, Atsunaga Kato, Yasushi Tokuda, Kenji Sakakibara
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 6 Pg. 999-1002 (Jun 2009) ISSN: 0385-0684 [Print] Japan
• PMID: 19542724 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• Deoxycytidine
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Gemcitabine

Topics

• Ampulla of Vater
• Antimetabolites, Antineoplastic (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Drug Combinations
• Duodenal Neoplasms (complications, drug therapy, surgery)
• Humans
• Jaundice, Obstructive (etiology)
• Male
• Middle Aged
• Oxonic Acid (administration & dosage)
• Tegafur (administration & dosage)
• Gemcitabine