Abstract | BACKGROUND: METHODS: Sleep was experimentally fragmented across all stages in 11 healthy, normal volunteers for two nights using auditory and mechanical stimuli. Primary outcomes included insulin sensitivity (S(I)), glucose effectiveness (S(G)), and insulin secretion, as determined by the intravenous glucose tolerance test. Secondary outcomes included measures of sympathovagal balance and serum levels of inflammatory markers, adipokines, and cortisol. RESULTS: Following two nights of sleep fragmentation, S(I) decreased from 5.02 to 3.76 (mU/L)(-1)min(-1) (P < .0001). S(G), which is the ability of glucose to mobilize itself independent of an insulin response, also decreased from 2.73 x 10(-2) min(-1) to 2.16 x 10(-2) min(-1) (P < .01). Sleep fragmentation led to an increase in morning cortisol levels and a shift in sympathovagal balance toward an increase in sympathetic nervous system activity. Markers of systemic inflammation and serum adipokines were unchanged with sleep fragmentation. CONCLUSIONS: Fragmentation of sleep across all stages is associated with a decrease in S(I) and S(G). Increases in sympathetic nervous system and adrenocortical activity likely mediate the adverse metabolic effects of poor sleep quality.
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Authors | Katherine A Stamatakis, Naresh M Punjabi |
Journal | Chest
(Chest)
Vol. 137
Issue 1
Pg. 95-101
(Jan 2010)
ISSN: 1931-3543 [Electronic] United States |
PMID | 19542260
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Blood Glucose
(metabolism)
- Circadian Rhythm
(physiology)
- Female
- Follow-Up Studies
- Glucose Tolerance Test
- Heart Rate
(physiology)
- Humans
- Insulin Resistance
(physiology)
- Male
- Polysomnography
- Prognosis
- Reference Values
- Sleep Deprivation
(blood, physiopathology)
- Young Adult
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