Abstract | BACKGROUND: OBJECTIVE: METHODS: We selected 6 single nucleotide polymorphisms in thymic stromal lymphopoietin and genotyped 5565 individuals from 4 independent asthma studies and tested for association with asthma, atopy, atopic asthma, and airway hyperresponsiveness by using a general allelic likelihood ratio test. P values were corrected for the effective number of independent single nucleotide polymorphisms and phenotypes. RESULTS: The A allele of rs1837253, which is 5.7 kb upstream of the transcription start site of the gene, was associated with protection from asthma, atopic asthma, and airway hyperresponsiveness, with the odds ratios and corrected P values for each being 0.79 and 0.0058; 0.75 and 0.0074; and 0.76 and 0.0094, respectively. Associations between thymic stromal lymphopoietin and asthma-related phenotypes were the most statistically significant observations in our study, which has to date examined 98 candidate genes. Full results are available online at http://genapha.icapture.ubc.ca/. CONCLUSIONS:
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Authors | Jian-Qing He, Teal S Hallstrand, Darryl Knight, Moira Chan-Yeung, Andrew Sandford, Ben Tripp, David Zamar, Yohan Bossé, Anita L Kozyrskyj, Alan James, Catherine Laprise, Denise Daley |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 124
Issue 2
Pg. 222-9
(Aug 2009)
ISSN: 1097-6825 [Electronic] United States |
PMID | 19539984
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Thymic Stromal Lymphopoietin
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Topics |
- Alleles
- Asthma
(genetics, physiopathology)
- Bronchial Hyperreactivity
(genetics)
- Cytokines
(genetics)
- Female
- Gene Expression
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linkage Disequilibrium
(genetics)
- Male
- Polymorphism, Single Nucleotide
- Sex Factors
- Thymic Stromal Lymphopoietin
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