Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate.

Abstract

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a clinically heterogeneous entity, encompassing a variety of debilitating conditions that have in common inflammation of the skeletal system and skin. To date, there is a paucity of documented efficacious treatment options. We report a 48-year-old man with skeletal and cutaneous signs and symptoms who improved dramatically after treatment with a combination of isotretinoin and pamidronate. This report provides an alternative treatment regimen for SAPHO that addresses the possible underlying pathophysiology of this likely underdiagnosed syndrome.

• Authors: Hassan Galadari, Alyssa G Bishop, Suraj S Venna, Emad Sultan, Daihung Do, Ross Zeltser
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 61 Issue 1 Pg. 123-5 (Jul 2009) ISSN: 1097-6787 [Electronic] United States
• PMID: 19539848 (Publication Type: Case Reports, Journal Article)

Chemical References

• Diphosphonates
• Isotretinoin
• Pamidronate

Topics

• Acneiform Eruptions (drug therapy)
• Diphosphonates (therapeutic use)
• Drug Therapy, Combination
• Humans
• Hyperostosis (drug therapy)
• Isotretinoin (therapeutic use)
• Male
• Middle Aged
• Osteitis (drug therapy)
• Pamidronate
• Psoriasis (drug therapy)
• Skin Diseases (drug therapy)
• Syndrome
• Synovitis (drug therapy)