[Expression of THY1 gene in epithelial ovarian cancer].

Abstract

OBJECTIVE:

To detect the expession of THY1 in ovarian serous cystadenocarcinoma tissues.

METHODS:

Immunohistochemistry was performed to detect the expression of THY1 gene in formalin-fixed, paraffin-embedded specimens of normal ovaries (n = 25), ovarian serous cystadenoma (n = 25), and serous cystadenocarcinoma (n = 53). The correlation of THY1 expression with clinicopathological parameters was statistically analyzed.

RESULTS:

The positive expression rates of THY1 protein in normal ovaries, ovarian serous cystadenomas and ovarian serous cystadenocarcinomas were 60.0% (15/25), 72.0% (18/25) and 34.0% (18/53), respectively. The values of IOD of THY1 protein expression were 288,449.2 +/- 60,087.3, 271,655.6 +/- 66,588.7 and 252,087.6 +/- 45,559.4, respectively. The expression of THY1 protein was significantly down-regulated in ovarian serous cystadenocarcinoma tissues compared with that in normal ovarian tissues and ovarian serous cystadenoma tissues (P < 0.05). THY1 expression was negatively correlated with surgical-pathological staging, histological differentiation and lymph node involvement (P < 0.05).

CONCLUSION:

The decreased level of THY1 expression may be related with the occurrence and development of ovarian serous cystadenocarcinoma.

• Authors: Li-qin Zeng, Zhi-lan Peng, Zhen-ling Duan
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 31 Issue 2 Pg. 118-20 (Feb 2009) ISSN: 0253-3766 [Print] China
• PMID: 19538887 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Thy-1 Antigens

Topics

• Adult
• Aged
• Cystadenocarcinoma, Serous (metabolism, pathology)
• Cystadenoma, Serous (metabolism, pathology)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Immunohistochemistry
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Staging
• Ovarian Neoplasms (metabolism, pathology)
• Thy-1 Antigens (metabolism)
• Young Adult