Abstract | OBJECTIVE: METHODS: Forty-five patients with BED or binge eating with sub-threshold symptoms (s-BED) with high eating impulsivity, received duloxetine 60-120 mg/day for 12 weeks. RESULTS: A significant reduction in number of binges/week was observed in BED patients; statistical analyses performed on the whole sample revealed significant reductions in scores on the binge eating scale ( BES) and the Beck depression inventory (BDI), weight, body mass index (BMI), clinical global impression, and the bulimia scale of the eating disorder inventory-2. The reduction in BES and BDI scores was not statistically different between BED and s-BED subjects. CONCLUSIONS: Although preliminary, results from this open trial suggest that duloxetine may be a successful option to reduce binge eating and depressive symptoms in both obese BED and s-BED outpatients.
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Authors | Paolo Leombruni, Luca Lavagnino, Filippo Gastaldi, Alessia Vasile, Secondo Fassino |
Journal | Human psychopharmacology
(Hum Psychopharmacol)
Vol. 24
Issue 6
Pg. 483-8
(Aug 2009)
ISSN: 1099-1077 [Electronic] England |
PMID | 19536908
(Publication Type: Clinical Trial, Journal Article)
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Copyright | 2009 John Wiley & Sons, Ltd. |
Chemical References |
- Serotonin Uptake Inhibitors
- Thiophenes
- Duloxetine Hydrochloride
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Topics |
- Adult
- Bulimia
(drug therapy, psychology)
- Depressive Disorder
(complications, drug therapy)
- Dose-Response Relationship, Drug
- Duloxetine Hydrochloride
- Female
- Humans
- Male
- Middle Aged
- Obesity
(complications)
- Pilot Projects
- Psychiatric Status Rating Scales
- Psychometrics
- Selective Serotonin Reuptake Inhibitors
(adverse effects, therapeutic use)
- Thiophenes
(adverse effects, therapeutic use)
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