Immune memory to hepatitis B virus in 4-9-year old children vaccinated in infancy with four doses of hexavalent DTPa-HBV-IPV/Hib vaccine.

Abstract

The combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio Haemophilus influenzae type b (DTPa-HBV-IPV/Hib) vaccine produces similar hepatitis B responses as the HBV monovalent vaccine. Booster vaccination of immunocompetent individuals primed against hepatitis B in infancy is currently not recommended. We investigated persisting immunity to hepatitis B in 4-6 (Study A; 106745) and 7-9 (Study B; 106744) year-old children primed in infancy and boosted in the second year of life with DTPa-HBV-IPV/Hib. Immunity was assessed by measuring persisting anti-HBs antibodies and evaluating the response to a challenge dose of HBV vaccine. At 4-6 years of age 86.0% of 186 subjects had persisting anti-HBs > or =10 mIU/ml increasing to 98.4% after the challenge. At 7-9 years of age, 78.0% of 186 subjects continued to have anti-HBs antibody concentrations > or =10 mIU/ml, increasing to 98.9% after the challenge. In both studies anti-HBs antibody GMC rose >80-fold. An anamnestic response to the HBV challenge was observed in 95.7% and 98.9% of subjects in Studies A and B, respectively. In both studies, 87% of 38 subjects with initially undetectable circulating anti-HBs antibodies (>3.3 IU/ml) achieved the 10 mIU/ml threshold after challenge; > or =97.0% of subjects with detectable antibodies before the challenge at least quadrupled their concentration. Post-vaccination anti-HBs concentrations were directly related to persisting antibody concentrations and the concentrations achieved after the booster dose in the second year of life. The HBV vaccine challenge dose was well tolerated. These studies show that primary and booster vaccination with combined DTPa-HBV-IPV/Hib (Infanrix hexa) induces sustained immune memory against hepatitis B up to age 9 years.

• Authors: Michael Zinke, Rudolf Kappes, Klaus Kindler, Anke Paulus-Koschik, Uwe Goering, Johann Disselhoff, Peter Soemantri, Detlef Grunert, Karl Heinz Laakmann, Ramakrishnan Gunasekaran, Britta Gartner, Jeanne-Marie Jacquet
• Journal: Human vaccines (Hum Vaccin) Vol. 5 Issue 9 Pg. 592-8 (Sep 2009) ISSN: 1554-8619 [Electronic] United States
• PMID: 19535920 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Haemophilus Vaccines
• Hepatitis B Antibodies
• Poliovirus Vaccine, Inactivated
• Vaccines, Combined

Topics

• Child
• Child, Preschool
• Diphtheria-Tetanus-acellular Pertussis Vaccines (immunology)
• Female
• Haemophilus Vaccines (immunology)
• Hepatitis B (prevention & control)
• Hepatitis B Antibodies (blood)
• Humans
• Immunologic Memory
• Male
• Poliovirus Vaccine, Inactivated (immunology)
• Time Factors
• Vaccines, Combined (immunology)