Abstract | BACKGROUND & OBJECTIVE: METHODS: Ninety seven women with endometriosis mean age (28.5 +/- 6.5 yr) diagnosed by laparoscopy and 102 women without endometriosis (28.4 +/- 4.8 yr) were included. Heparinised blood samples were collected from all for DNA isolation and estimation of PCBs. GSTM1 genotyping was done by PCR and PCBs were estimated by gas chromatography. RESULTS: Women with endometriosis showed significantly higher concentrations of PCBs compared with control group. Twenty six (26.8%) women with endometriosis and 15 (14.7%) of the controls had the GSTM1 null (*0/*0) genotype [odds ratio (OR = 2.12, 95% confidence interval (CI) = 1.045-4.314], which showed significant association (P = 0.03) with endometriosis. The association between the concentrations of PCBs, GSTM1 null genotype and different severity of endometriosis was significant (P<0.05) for all four compounds and GSTM1 (PCB1: r = +0.5388, P<0.0001; PCB5: r = +0.6753, P<0.0001; PCB29: r = +0.6471, P<0.0001; and PCB98: r = +0.4357, P<0.0001; GSTM1: r = +0.9439, P = 0.05). INTERPRETATION & CONCLUSION: The study results suggested that women having higher concentration of PCBs and GSTM1 null (*0/*0) polymorphism might have an increased susceptibility of endometriosis. The findings need to be confirmed in a larger sample.
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Authors | Rozati Roya, Giragalla Simha Baludu, B Satyanarayana Reddy |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 129
Issue 4
Pg. 395-400
(Apr 2009)
ISSN: 0971-5916 [Print] India |
PMID | 19535834
(Publication Type: Journal Article)
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Chemical References |
- Polychlorinated Biphenyls
- Glutathione Transferase
- glutathione S-transferase M1
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Topics |
- Adult
- Case-Control Studies
- Chromatography, Gas
- Endometriosis
(chemically induced, genetics)
- Female
- Glutathione Transferase
(genetics)
- Humans
- Mutation
(genetics)
- Odds Ratio
- Polychlorinated Biphenyls
(blood, toxicity)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prospective Studies
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