Differential associations between brain 5-HT(1A) receptor binding and response to pain versus touch.

Abstract

We studied whether brain serotonin 5-HT(1A) receptor availability is associated with response to noxious heat versus tactile stimuli, and short-term memory for heat pain. Psychophysical performance was assessed in 16 healthy subjects who had participated in a positron emission tomography study using [carbonyl-11C]WAY-100635 ligand for the assessment of 5-HT(1A) receptor binding potential (BP (ND)). Signal detection theory was applied to allow separate analysis of the subject's sensory-discriminative capacity (sensory factor) and the attitude toward reporting a sensation (response criterion; non-sensory factor). Subject's response criterion for heat pain was inversely correlated with 5-HT(1A) BP (ND) in the dorsal raphe, middle temporal gyrus, orbitofrontal cortex and posterior cingulum, whereas the subject's discriminative capacity for touch was inversely correlated with 5-HT(1A) BP (ND) in the cingulum, inferior temporal gyrus, and medial prefrontal cortex. Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe.

• Authors: Ilkka K Martikainen, Jussi Hirvonen, Ullamari Pesonen, Nora Hagelberg, Heikki Laurikainen, Heikki Tuikkala, Jaana Kajander, Kjell Någren, Jarmo Hietala, Antti Pertovaara
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 116 Issue 7 Pg. 821-30 (Jul 2009) ISSN: 1435-1463 [Electronic] Austria
• PMID: 19533293 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Piperazines
• Pyridines
• Serotonin Antagonists
• Receptor, Serotonin, 5-HT1A
• Serotonin
• N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide

Topics

• Adult
• Binding, Competitive (drug effects, physiology)
• Brain (metabolism, physiopathology)
• Brain Mapping
• Cerebral Cortex (anatomy & histology, diagnostic imaging, metabolism)
• Female
• Humans
• Male
• Memory, Short-Term (drug effects, physiology)
• Pain (diagnostic imaging, metabolism, physiopathology)
• Pain Threshold (physiology)
• Physical Stimulation
• Piperazines (metabolism)
• Positron-Emission Tomography
• Psychophysics (methods)
• Pyridines (metabolism)
• Radioligand Assay
• Raphe Nuclei (anatomy & histology, diagnostic imaging, metabolism)
• Receptor, Serotonin, 5-HT1A (metabolism)
• Serotonin (metabolism)
• Serotonin Antagonists (metabolism)
• Signal Detection, Psychological (physiology)
• Touch (physiology)