Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo.

Abstract

Umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. In continuation of our earlier in-vitro finding, we determined to assess the cancer chemopreventive activity of umbelliprenin in vivo by using a two-stage carcinogenesis assay of mouse skin tumors induced by peroxynitrite as an initiator and TPA (12-O-tetradecanoylphorbol-13-acetate) as a promoter. In this assay, treatment with umbelliprenin along with peroxynitrite/TPA delayed the formation of papillomas up to week 9, and approximately 33.3 and 86.6% of the mice bore papillomas after 11 and 20 weeks of promotion, respectively. Umbelliprenin reduced the number of tumors per mouse by 45% after 20 weeks of promotion compared with the control group. Interestingly, this is equal to the corresponding value (45%) for curcumin, used as a reference standard compound in our study. In addition, the pattern of tumor promotion was slower in mice treated with umbelliprenin compared with the curcumin. Therefore, umbelliprenin might be valuable as a cancer chemopreventive agent.

• Authors: Mehrdad Iranshahi, Amirhossein Sahebkar, Midori Takasaki, Takao Konoshima, Harukuni Tokuda
• Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) (Eur J Cancer Prev) Vol. 18 Issue 5 Pg. 412-5 (Sep 2009) ISSN: 1473-5709 [Electronic] England
• PMID: 19531956 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Carcinogens
• Umbelliferones
• Peroxynitrous Acid
• umbelliprenin

Topics

• Animals
• Anticarcinogenic Agents (therapeutic use)
• Carcinogens
• Disease Models, Animal
• Female
• Mice
• Papilloma (chemically induced, prevention & control)
• Peroxynitrous Acid
• Skin Neoplasms (chemically induced, prevention & control)
• Umbelliferones (therapeutic use)