[Alimentary methods of maintaining the superoxide dismutase activity in the tissues of rats during growth of a transplanted tumor and administration of carminomycin].

Abstract

The aim of the experiment was to study the effect of three specialized food rations on activity of superoxide dismutase (SOD) in tissues of rats with transplanted Walker's carcinosarcoma 256 exposed to carminomycin. It was shown that the three specialized rations were able to significantly modify the SOD activity in the tissues of the rats with Walker's carcinosarcoma 256 at the background of treatment with carminomycin. Thus, the ration enriched with copper and zinc salts and folic acid activated SOD in the animals of all the groups. Still, the effect was higher in the tumor-bearing animals and the rats treated with carminomycin i.e. under conditions of oxidative stress. The use of the ration enriched with sulfur-containing amino acids, sodium selenide and vitamin E led to decreasing of the efficiency of the fermentative dismutation of O2 in the healthy rats and marked activating of SOD in the tumor-bearing animals. The ration containing lyophilized vegetables and vitamin E provided a significant increase in the SOD activity in the healthy rats. However, its potential was not sufficient for overcoming the SOD inhibiting effect of the tumor growth.

• Authors: E G Lenskaia, Sh S Tazhibaev, N M Karsybekova, N R Alekseeva, V T Sarbaev
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 36 Issue 7 Pg. 32-4 (Jul 1991) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Alimentarnye sposoby podderzhaniia superoksiddismutaznoĭ aktivnosti v tkaniakh krys v usloviiakh rosta transplantirovannoĭ opukholi i vvedeniia karminomitsina.
• PMID: 1953187 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Copper
• Folic Acid
• Carubicin
• Superoxide Dismutase
• Zinc
• Copper Sulfate

Topics

• Animal Feed
• Animals
• Carcinoma 256, Walker (drug therapy, enzymology, pathology)
• Carubicin (therapeutic use)
• Copper (administration & dosage)
• Copper Sulfate
• Folic Acid (administration & dosage)
• Liver (enzymology)
• Male
• Neoplasm Transplantation
• Rats
• Skin Neoplasms (drug therapy, enzymology, pathology)
• Superoxide Dismutase (antagonists & inhibitors, metabolism)
• Zinc (administration & dosage)