Protegentin is a combined preparation in the form of
ointment containing 0.1 per cent of
gentamicin, 0.25 per cent of
erythromycin and 0.1 per cent of
protease C. Pharmacokinetic studies on the preparation were conducted.
Protegentin and
gentamicin ointment, currently manufactured in this country, were applied to the surface of experimental pure cutaneous
wounds in guinea pigs in a dose of 1 g. It was shown that inspite of the same contents of
gentamicin in the
ointments, the mean maximum concentration of the
antibiotic in the underlying muscular tissue after the
protegentin application was somewhat higher than that after the use of the
gentamicin ointment. The differences in the
drug concentration maintained during the whole observation period of 24 hours. However, they were not statistically significant. The
gentamicin concentrations in serum after the use of
protegentin were also somewhat higher than those after application of the
gentamicin ointment (the differences were not statistically significant). Still, in no case the concentrations reached the potentially toxic ones. The
erythromycin concentrations in the muscular tissue were much higher than those in the blood.