[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.

Abstract

[6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts its chemopreventive effects remains elusive. The leukotriene A(4) hydrolase (LTA(4)H) protein is regarded as a relevant target for cancer therapy. Our in silico prediction using a reverse-docking approach revealed that LTA(4)H might be a potential target of [6]-gingerol. We supported our prediction by showing that [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA(4)H activity in HCT116 colorectal cancer cells. We showed that [6]-gingerol effectively suppressed tumor growth in vivo in nude mice, an effect that was mediated by inhibition of LTA(4)H activity. Collectively, these findings indicate a crucial role of LTA(4)H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA(4)H for the prevention of colorectal cancer.

• Authors: Chul-Ho Jeong, Ann M Bode, Angelo Pugliese, Yong-Yeon Cho, Hong-Gyum Kim, Jung-Hyun Shim, Young-Jin Jeon, Honglin Li, Hualiang Jiang, Zigang Dong
• Journal: Cancer research (Cancer Res) Vol. 69 Issue 13 Pg. 5584-91 (Jul 01 2009) ISSN: 1538-7445 [Electronic] United States
• PMID: 19531649 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Catechols
• Fatty Alcohols
• gingerol
• Epoxide Hydrolases
• leukotriene A4 hydrolase

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Catechols (pharmacology, therapeutic use)
• Cell Division (drug effects)
• Cell Line, Tumor
• Colonic Neoplasms (enzymology, prevention & control)
• Colorectal Neoplasms (enzymology, pathology, prevention & control)
• Epoxide Hydrolases (antagonists & inhibitors, chemistry)
• Fatty Alcohols (pharmacology, therapeutic use)
• Female
• Ginger
• HCT116 Cells (drug effects)
• Humans
• Male
• Mice
• Mice, Nude
• Models, Molecular
• Protein Conformation