Abstract | CONTEXT: OBJECTIVE: The aim of the study was to measure plasma FGF21 during fasting, ketogenic diet, and PPAR agonist treatment in humans. DESIGN AND SETTING: We conducted a prospective study involving three patient groups at two university hospitals. PATIENTS: MAIN OUTCOME MEASURES: RESULTS: CONCLUSION:
FGF21 does not play a major role in regulating the fasting response or ketosis in man. However, plasma FGF21 is elevated in response to pharmacological activation of PPAR alpha and PPAR delta and may contribute to the beneficial metabolic effects observed in response to pharmacotherapy with these compounds.
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Authors | Constantinos Christodoulides, Pamela Dyson, Dennis Sprecher, Kostas Tsintzas, Fredrik Karpe |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 94
Issue 9
Pg. 3594-601
(Sep 2009)
ISSN: 1945-7197 [Electronic] United States |
PMID | 19531592
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Peroxisome Proliferator-Activated Receptors
- fibroblast growth factor 21
- Fibroblast Growth Factors
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Topics |
- Adult
- Diet, Ketogenic
- Fibroblast Growth Factors
(blood, physiology)
- Humans
- Ketosis
(etiology)
- Male
- Peroxisome Proliferator-Activated Receptors
(agonists)
- Prospective Studies
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