5-Hydroxymethylfurfural and 5-sulfooxymethylfurfural increase adenoma and flat ACF number in the intestine of Min/+ mice.

Abstract

BACKGROUND:

5-Hydroxymethylfurfural (HMF) is produced in large quantities during the processing of food containing carbohydrates and can be metabolised to 5-sulfooxymethylfurfural (SMF), a reactive intermediate that can bind to DNA and cause mutagenic effects.

MATERIALS AND METHODS:

Three to six days after birth, multiple intestinal neoplasia (Min/+) mice were given a single subcutaneous injection of either 500 mg/kg body weight (bw) HMF, 25 mg/kg bw SMF or vehicle (0.9 % NaCl), and were euthanised at 12 weeks of age. The number and size of adenomas and flat aberrant crypt foci (ACF) were counted in the intestine.

RESULTS:

HMF increased the number of small intestinal adenomas (p=0.033), whereas SMF increased the flat ACF number in the large intestine (p=0.025). Treatment with HMF and SMF had no effect on the size of the adenomas.

CONCLUSION:

These results show that both HMF and SMF are weak intestinal carcinogens in Min/+ mice.

• Authors: Camilla Svendsen, Trine Husøy, Hansruedi Glatt, Jan Erik Paulsen, Jan Alexander
• Journal: Anticancer research (Anticancer Res) Vol. 29 Issue 6 Pg. 1921-6 (Jun 2009) ISSN: 0250-7005 [Print] Greece
• PMID: 19528448 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 5-sulfooxymethylfurfural
• Adenomatous Polyposis Coli Protein
• Carcinogens
• 5-hydroxymethylfurfural
• Furaldehyde

Topics

• Adenoma (chemically induced, pathology)
• Adenomatous Polyposis Coli Protein (physiology)
• Animals
• Carcinogens (toxicity)
• Female
• Furaldehyde (analogs & derivatives, toxicity)
• Intestinal Neoplasms (chemically induced, pathology)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Necrosis
• Precancerous Conditions (pathology)