Myelopeptide-5 abolishes virus-induced immunosuppression by restoring T cell functions.

Abstract

Myelopeptide-5 (MP-5; synthetic analog of endogenous low-molecular-weight peptide Val-Val-Tyr-Pro-Asp) neutralized the immunosuppressive effects of antiviral vaccines (influenza, measles, and measles/parotitis) and stimulated their immunogenicity by restoring functional activity of T cells, suppressed by the viruses. Specific binding of MP-5 to CD4(+) lymphocyte (its target cell) was studied using [(3)H]MP-5 (dissociation constant 2.03 x 10(-7) M).

• Authors: R G Belyovskaya, M V Kalyuzhnaya, V P Shevchenko, E A Kirilina
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 147 Issue 1 Pg. 59-62 (Jan 2009) ISSN: 0007-4888 [Print] United States
• PMID: 19526132 (Publication Type: Journal Article)

Chemical References

• Oligopeptides
• Viral Vaccines
• valyl-valyl-tyrosyl-prolyl-aspartic acid

Topics

• Animals
• Guinea Pigs
• Immune Tolerance (drug effects)
• Oligopeptides (pharmacology)
• Rats
• T-Lymphocytes (drug effects, immunology)
• Viral Vaccines (pharmacology)