Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine (1a).

Abstract

To further pursue the antineoplastic leads offered by our isolation of trans-dihydronarciclasine (1a) and 7-deoxy-trans-dihydronarciclasine (1c) from two medicinal plant species of the Amaryllidaceae family, a practical palladium-catalyzed hydrogenation procedure was developed for the synthesis of these isocarbostyrils from narciclasine (2a) and 7-deoxynarciclasine (2c).

• Authors: George R Pettit, Sylvie Ducki, Stephen A Eastham, Noeleen Melody
• Journal: Journal of natural products (J Nat Prod) Vol. 72 Issue 7 Pg. 1279-82 (Jul 2009) ISSN: 1520-6025 [Electronic] United States
• PMID: 19522518 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• 7-deoxy-trans-dihydronarciclasine
• Alkaloids
• Amaryllidaceae Alkaloids
• Antineoplastic Agents, Phytogenic
• Isoquinolines
• Phenanthridines
• narciclasine
• dihydronarciclasine
• Palladium

Topics

• Alkaloids (chemical synthesis, chemistry, pharmacology)
• Amaryllidaceae Alkaloids
• Antineoplastic Agents, Phytogenic (chemical synthesis, chemistry, pharmacology)
• Catalysis
• Isoquinolines (chemical synthesis, chemistry, pharmacology)
• Molecular Structure
• Narcissus (chemistry)
• Palladium (chemistry)
• Phenanthridines
• Plants, Medicinal (chemistry)
• Stereoisomerism