Abstract | AIM: METHOD: Male C57Bl6/J mice were fed control chow, a HF diet or a HF diet supplemented with SP (50 or 100 mg/kg/day). RESULTS:
Body weight gain and total body fat content of SP-treated animals were significantly reduced compared with HF-fed mice. Fractional synthesis of palmitate was significantly reduced in mice treated with SP, indicative for ACC1 inhibition. Plasma beta-hydroxybutyrate levels were significantly elevated by SP, reflecting simultaneous inhibition of ACC2 activity. Mice treated with SP showed improved peripheral insulin sensitivity, as assessed by hyperinsulinaemic euglycaemic clamps. CONCLUSION: Pharmacological inhibition of the ACC system is of potential use for treatment of key components of the metabolic syndrome.
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Authors | M Schreurs, T H van Dijk, A Gerding, R Havinga, D-J Reijngoud, F Kuipers |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 11
Issue 10
Pg. 987-91
(Oct 2009)
ISSN: 1463-1326 [Electronic] England |
PMID | 19519866
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Fats
- Insulin
- Macrolides
- RNA, Mitochondrial
- soraphen A
- Palmitic Acid
- RNA
- Cholesterol
- Acetyl-CoA Carboxylase
- 3-Hydroxybutyric Acid
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Topics |
- 3-Hydroxybutyric Acid
(blood)
- Acetyl-CoA Carboxylase
(antagonists & inhibitors)
- Animals
- Cholesterol
(metabolism)
- Diet
- Dietary Fats
(administration & dosage)
- Glucose Clamp Technique
- Insulin
(metabolism)
- Insulin Resistance
(physiology)
- Liver
(metabolism)
- Macrolides
(pharmacology)
- Male
- Mice
- Mice, Inbred BALB C
- Obesity
(metabolism, physiopathology)
- Palmitic Acid
(metabolism)
- Polymerase Chain Reaction
(methods)
- RNA
(metabolism)
- RNA, Mitochondrial
- Weight Gain
(drug effects)
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