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Granulomatous inflammation in the lungs of mice with systemic candidiasis receiving a composition of amphotericin B and dialdehyde dextran.

Abstract
A composition of amphotericin B and dialdehyde dextran was used for the therapy of male C57Bl/6 mice with systemic candidiasis. The composition was more effective than free amphotericin B. A decrease in the number and size of candidal granulomas in the lungs was more significant after therapy with the study composition (compared to free amphotericin B).
AuthorsV A Shkurupiy, T G Chernova, A P Nadeev
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 146 Issue 6 Pg. 829-31 (Dec 2008) ISSN: 1573-8221 [Electronic] United States
PMID19513397 (Publication Type: Journal Article)
Chemical References
  • Antifungal Agents
  • Dextrans
  • dextran dialdehyde
  • Amphotericin B
Topics
  • Amphotericin B (therapeutic use)
  • Animals
  • Antifungal Agents (therapeutic use)
  • Candidiasis (drug therapy, immunology)
  • Dextrans (therapeutic use)
  • Granuloma (drug therapy, immunology, pathology)
  • Inflammation (drug therapy, immunology)
  • Lung Diseases, Fungal (drug therapy, immunology)
  • Male
  • Mice
  • Mice, Inbred C57BL

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