| Abstract | OBJECTIVE: Narcolepsy (with and without cataplexy) and idiopathic hypersomnia, are disorders with common features but with different HLA-DQB1*0602 allele prevalence. The present study describes the prevalence of HLA-DQB1*0602 allele in narcoleptics with and without cataplexy and in patients with idiopathic hypersomnia. METHOD: Subjects comprised 68 patients who were diagnosed for narcolepsy or idiopathic hypersomnia and 23 healthy controls according to the International Classification of Sleep Disorders-2. Subjects comprised 43 patients with narcolepsy and cataplexy, 11 patients with narcolepsy but without cataplexy, 14 patients with idiopathic hypersomnia and 23 healthy controls. Genotyping of HLA-DQB1*0602 allele was performed for all subjects. RESULTS: The prevalence of the HLA-DQB1*0602 allele was increased in idiopathic hypersomnia and in narcoleptic patients with and without cataplexy when compared to healthy subjects (p = 0.04; p = 0.03 and p < 0.0001, respectively). CONCLUSIONS: This finding is in accordance with those of previous studies. The gold standard exam of narcolepsy with cataplexy is Hypocretin-1 dosage, but in patients without cataplexy and idiopathic hypersomnia, there are no specific diagnostic lab findings. The presence of the HLA-DQB1* 0602 allele may be important for the differential diagnosis of situations that resemble those sleep disorders such as secondary changes in sleep structure due to drugs' consumption. |
| Authors | Fernando Morgadinho Santos Coelho, Márcia Pradella-Hallinan, Mario Predazzoli Neto, Lia Rita Azeredo Bittencourt, Sérgio Tufik
(Affiliation: Psychobiology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil. fernandomorgadinho at hotmail.com)
|
| Journal | Revista brasileira de psiquiatria (São Paulo, Brazil : 1999)
(Rev Bras Psiquiatr)
Vol. 31
Issue 1
Pg. 10-4
(Mar 2009)
ISSN: 1516-4446 [Print] Brazil |
| PMID | 19506770
(Publication Type: Journal Article)
|
| Chemical References |
- HLA-DQ Antigens
- HLA-DQB1 protein, human
- Membrane Glycoproteins
|
| Topics |
- Adolescent
- Adult
- Aged
- Alleles
- Brazil
- Case-Control Studies
- Chi-Square Distribution
- Child, Preschool
- Diagnosis, Differential
- Female
- HLA-DQ Antigens
(genetics)
- Humans
- Hypersomnolence, Idiopathic
(diagnosis, genetics)
- Male
- Membrane Glycoproteins
(genetics)
- Middle Aged
- Narcolepsy
(diagnosis, genetics)
- Statistics, Nonparametric
- Young Adult
|
