Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum.

Abstract

Artemisone (single oral dose, 10 mg/kg of body weight) cured nonimmune Aotus monkeys of their Plasmodium falciparum infections when combined with mefloquine (single oral dose, 5 and 10 mg/kg but not 2.5 mg/kg). In combination with amodiaquine (20 mg/kg/day), artemisone (10 mg/kg/day) given orally for 3 days cured all infected monkeys. Three days of treatment with artemisone (30 mg/kg/day) and clindamycin (100 mg/kg/day) was also curative.

• Authors: Nicanor Obaldia 3rd, Barbara M Kotecka, Michael D Edstein, Richard K Haynes, Burkhard Fugmann, Dennis E Kyle, Karl H Rieckmann
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 8 Pg. 3592-4 (Aug 2009) ISSN: 1098-6596 [Electronic] United States
• PMID: 19506062 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimalarials
• Artemisinins
• Amodiaquine
• artemisone
• Mefloquine

Topics

• Amodiaquine (therapeutic use)
• Animals
• Antimalarials (therapeutic use)
• Aotus trivirgatus
• Artemisinins (therapeutic use)
• Drug Therapy, Combination
• Malaria, Falciparum (drug therapy)
• Mefloquine (therapeutic use)
• Parasitic Sensitivity Tests
• Plasmodium falciparum (physiology)
• Treatment Outcome