Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007.

Abstract

Of 3,004 gram-negative bacilli collected from intra-abdominal infections in the Asia-Pacific region during 2007, 42.2% and 35.8% of Escherichia coli and Klebsiella spp., respectively, were extended-spectrum beta-lactamase (ESBL) positive. Moreover ESBL rates in India for E. coli, Klebsiella pneumoniae, and Klebsiella oxytoca were 79.0%, 69.4%, and 100%, respectively. ESBL-positive E. coli rates were also relatively high in China (55.0%) and Thailand (50.8%). Ertapenem and imipenem were the most active drugs tested, inhibiting over 90% of all species, including ESBL-positive isolates with the exception of Pseudomonas aeruginosa isolates (<90% susceptible to all study drugs) and ESBL-positive Klebsiella pneumoniae isolates (<90% susceptible to all study drugs except imipenem). Quinolones achieved 90% inhibition levels only against ESBL-negative K. pneumoniae and ESBL-negative K. oxytoca. A decline in ampicillin-sulbactam activity was noted, with only 34.5% of all Enterobacteriaceae inhibited in this study.

• Authors: Stephen P Hawser, Samuel K Bouchillon, Daryl J Hoban, Robert E Badal, Po-Ren Hsueh, David L Paterson
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 8 Pg. 3280-4 (Aug 2009) ISSN: 1098-6596 [Electronic] United States
• PMID: 19506060 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Quinolones
• beta-Lactams
• Imipenem
• beta-Lactamases
• Ertapenem

Topics

• Anti-Bacterial Agents (pharmacology)
• China
• Drug Resistance, Bacterial
• Ertapenem
• Escherichia coli (drug effects, enzymology)
• Gram-Negative Bacteria (drug effects, enzymology, isolation & purification)
• Gram-Negative Bacterial Infections (microbiology)
• Imipenem (pharmacology)
• India
• Klebsiella (drug effects, enzymology)
• Quinolones (pharmacology)
• Thailand
• beta-Lactamases (metabolism)
• beta-Lactams (pharmacology)