HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Systemic lupus erythematosus, complicated with refractory skin ulcers, treated successfully with bosentan.

Abstract
A 20-year-old woman was admitted to our hospital because of bilateral pretibial edema. Administration of prednisolone was started after she was diagnosed with systemic lupus erythematosus (SLE). However, skin ulcers on her extremities developed; they subsequently worsened with tapering of prednisolone. She also developed pulmonary hypertension (PH). Her skin ulcers improved considerably after administration of bosentan, an endothelin receptor antagonist. Bosentan may be efficacious not only for PH but also for refractory skin ulcers.
AuthorsEiji Suzuki, Hyo Kyozuka, Toru Nishida, Takashi Kanno, Hiromasa Ohira
JournalModern rheumatology (Mod Rheumatol) Vol. 19 Issue 4 Pg. 447-51 ( 2009) ISSN: 1439-7595 [Print] England
PMID19504167 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antihypertensive Agents
  • Sulfonamides
  • Bosentan
Topics
  • Adult
  • Antihypertensive Agents (therapeutic use)
  • Bosentan
  • Extremities (pathology)
  • Female
  • Humans
  • Hypertension, Pulmonary (drug therapy, etiology, pathology)
  • Lupus Erythematosus, Systemic (complications, drug therapy, pathology)
  • Skin Ulcer (drug therapy, etiology, pathology)
  • Sulfonamides (therapeutic use)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: